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br Material and methods br Results br
2024-06-07
Material and methods Results Discussion GRK2 activity has increasingly been shown to contribute to the progression of numerous diseases and organ dysfunction [5], [6]. For instance, a large body of work over the last two decades has identified GRK2 as a major regulator of cardiac dysfunctio
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The purpose of the present study is
2024-06-07
The purpose of the present study is (1) to characterize AChE from the monogonont B. koreanus and to analyze the modulation of the AChE activity and its transcription level after exposure to six pharmaceuticals, (2) to evaluate the usefulness of AChE as a molecular biomarker upon pharmaceutical expos
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To reconstruct the amino acid sequence of
2024-06-07
To reconstruct the amino AEBSF mg sequence of an ancestral β subunit a molecular phylogeny is required, which is inferred from a β subunit sequence alignment. To build this alignment we searched the NCBI database for proteins similar in sequence to the human muscle-type β subunit precursor protein,
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mecamylamine An alternative to the agonist or antagonist
2024-06-07
An alternative to the agonist or antagonist potential in drug discovery is the positive allosteric modulator (PAM) approach, which can augment the normal processes of neurotransmission as opposed to directly replacing or antagonizing them. PAMs are thought to bind to sites that are distinct from the
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Consistent with the observation that mutations in the redox
2024-06-07
Consistent with the observation that mutations in the redox-partner binding site of P450c17 that reverse charge from basic to acidic (R347H, R358Q) cause 17,20-lyase deficiency (Geller et al, 1997, Geller et al, 1999), at least one POR mutation that changes a residue in the FMN domain from neutral t
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In this paper we describe the
2024-06-07
In this paper, we describe the formation of a structure-based pharmacophore which lead to the discovery of several hydrophobic, yet non-lipid inhibitors of ATX. These compounds docked within the same volume occupied by the initial non-lipid inhibitors of ATX used to build the pharmacophore. Violatio
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On the contrary evidence also suggests that
2024-06-07
On the contrary, evidence also suggests that autophagy plays a striking protective role in cancer cells. Highly burgeoning cancer nuciferine synthesis require cellular building blocks for their metabolism and energy production. At this stage of cancer development, autophagy acts as a friend providin
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Granzyme B Inhibitor Z-AAD-CH2Cl receptor Jesus et al discov
2024-06-07
Jesus et al. discovered a new series of azaindole as Aurora inhibitors through various modification of GSK1070916 (47). They synthesized series from modification of the GSK1070916 and evaluated for in-vitro Aurora-B/INCENP and Aurora-A/TPX2 inhibition assays. Modified Granzyme B Inhibitor Z-AAD-CH2C
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br Experimental section br Acknowledgments br Introduction A
2024-06-07
Experimental section Acknowledgments Introduction Adipose is a major endocrine organ which releases a range of bioactive agents [1]. Selected adipose depots have been established as sites of sex steroid metabolism [1]. Subcutaneous and visceral adipose express high levels of aromatase, cap
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br Funding This work was supported by
2024-06-06
Funding This work was supported by the National Natural Science Foundation of China (grant No. 81573664). Thanks to Jing-xian Yang from the Pharmacology Laboratory of Liaoning University of Traditional Chinese Medicine for support with technology and experimental equipment. Disclosure Confl
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br Materials and methods br Results and discussion
2024-06-06
Materials and methods Results and discussion First, we examined whether hypothalamic Akt-mediated signaling pathways are regulated postprandially in chickens. Refeeding significantly (P Spectinomycin hydrochloride hydrate concentrations significantly increased in chicks after 1 h of refeeding
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The functional observations from the
2024-06-06
The functional observations from the present study are based on neoplastic pentylenetetrazol australia (HSY), and comparative expressions between normal salivary and pleomorphic adenoma tissues. However, there is a paucity of information on AhR expression and function in normal salivary gland, not
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In a recent series of
2024-06-06
In a recent series of studies from our laboratory, to characterize the contractile systems within the rat SecinH3 wall, three conditions were identified that led to detrusor activity: spontaneous micro-contractions, electrical field stimulated (EFS) contractions and muscarinic agonist induced contr
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br Functional consequences of ADK regulation
2024-06-06
Functional consequences of ADK regulation on astrocyte function As outlined above (see introduction), ADK critically regulates the extracellular adenosine levels in NADP/NADPH Quantitation Colorimetric Kit (Boison, 2006, Etherington et al., 2009). Changes in the levels of adenosine, as a result
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While the direct effects of ARI lead to a
2024-06-06
While the direct effects of 5-ARI lead to a dramatic Amyloid β-Peptide (1-42) in serum DHT levels, other laboratory values are also affected by 5-ARI use. Serum testosterone elevations are known to occur with both finasteride and dutasteride use, but values will typically remain within the normal la
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