• The first natural product described as LO inhibitor was

  2023-11-18

  

  The first natural product described as 5-LO inhibitor was the polyphenol nordihydroguaiaretic NPS-2143 from the Mexican dessert plant Larrea divaricata in 1981 (Bokoch and Reed, 1981), short after the initial identification of 5-LO in 1979 (Borgeat and Samuelsson, 1979). Long time before mPGES-1 wa

• The analysis of the profile of protein phosphorylation

  2023-11-18

  

  The analysis of the profile of protein phosphorylation in MMS-treated CVT 10216 confirmed that both the ATM and ATR pathways were activated in S-phase blocked cells. Interestingly, phosphorylation of Chk1 was observed 24h after MMS-treatment both in AT- and ATM-inhibited cells, whilst in the absenc

• br In vivo visualization of aromatase with positron

  2023-11-18

  

  In vivo visualization of aromatase with positron emission tomography (PET) Positron emission tomography (PET) utilizes the high conotoxin synthesis photons formed during the annihilation of positrons to detect the changes in the amount and localization of injected radiopharmaceuticals in the liv

• br Materials and methods br Results and discussion

  2023-11-17

  

  Materials and methods Results and discussion Conclusion Introduction Free radicals produced by normal oxidative metabolism in the human body can cause chain oxidation of food, accelerate food deterioration and cause serious problems of food safety (Choe & Min, 2006). Excess free radicals

• br Natriuretic peptides and neprilysin Left ventricular

  2023-11-17

  

  Natriuretic peptides and neprilysin Left ventricular systolic function, most commonly due to myocardial damage as a consequence of coronary artery disease, hypertension or both, and leading to sustained, pathological activation of the renin angiotensin ras inhibitor system (RAAS) and sympathetic

• br Materials and Methods br Results A

  2023-11-17

  

  Materials and Methods Results A total of 28 NSCLC tumor samples from 26 patients (2 patients with paired tumor samples) were included. According to the initial FISH (Abbott Molecular probes) and IHC results, 13 samples were ALK IHC+FISH+, 5 samples were ALK IHC+FISH−, 2 samples (from the same

• Aldose reductase AR is an

  2023-11-17

  

  Aldose reductase (AR), is an NADPH-dependent aldo-keto reductase very well studied as a catalyst of glucose conversion to sorbitol in the polyol pathway [11], [12]. In the diabetic lens characterized by chronically high levels of glucose, AR is responsible for production of high levels of sorbitol a

• CX-5461 Patients with ADA SCID may experience autoimmune AEs

  2023-11-17

  

  Patients with ADA-SCID may experience autoimmune AEs after SCT (and/or during ERT) that are thought to be related to immune dysregulation prior to achieving complete immune reconstitution. The more common autoimmune manifestations include hemolytic anemia, hypothyroidism, and immune thrombocytopenia

• Introduction Pyometra is relatively common in intact bitches

  2023-11-17

  

  Introduction Pyometra is relatively common in intact bitches and its diagnosis is aided by ultrasonography (Bigliardi et al., 2004), along with measurement of acute phase proteins and leucocyte (white blood cell, WBC) counts; assessment of these parameters during recovery may be helpful for monitor

• Despite these efforts to prevent oxidative metabolic degrada

  2023-11-17

  

  Despite these efforts to prevent oxidative metabolic degradation, and showed only marginal improvements in metabolic stability and still exhibited high plasma clearances as shown in . High molecular weight as well as relative high log values could be contributing factors to the poor PK profiles of

• Interestingly a homolog of C elegans acr is present in

  2023-11-17

  

  Interestingly, a homolog of C. elegans acr-23 is present in the A. suum WP1066 australia (Jex et al., 2011). However, A. suum is not susceptible to monepantel treatment in vivo (Tritten et al., 2011). Our research seeks to advance knowledge on the mode of action of monepantel on nAChRs from Clade II

• In addition to the above

  2023-11-17

  

  In addition to the above-mentioned synaptic mechanisms, the serotonergic system also has a critical role in the antidepressant effects of mGlu2/3 receptor antagonists. Indeed, we previously reported that mGlu2/3 receptor antagonists increased the firing rate of serotonin neurons in the dorsal raphe

• br Materials and methods br Results

  2023-11-17

  

  Materials and methods Results Discussion Recent studies have highlighted Ozagrel and autophagy as novel targets for the treatment of liver fibrosis [7,14]. In this study, we demonstrated that catalpol protected the rat liver from CCl4-caused injury and fibrogenesis in vivo and in vitro for

• Functional enhancers are often composed of binding motifs of

  2023-11-16

  

  Functional enhancers are often composed of binding motifs of multiple key transcription factors to confer spatial and temporal regulation of genes in a certain context. In the uterus, the difference between the number of genes that have associated PGR occupancy and that of progesterone responsive ge

• Further important evidence for G

  2023-11-16

  

  Further important evidence for G protein signaling on early endosomes has been subsequently obtained for the β2-adrenegic receptor using fluorescently-tagged conformation-sensitive nanobodies selectively recognizing the active receptor and Gs protein [43]. More recently, our group used a combinatio

14981 records 242/999 page Previous Next First page 上5页 241242243244245 下5页 Last page