• In conclusion re evaluation of HER status

  2022-03-14

  

  In conclusion, re-evaluation of HER2 status is necessary to determine the appropriate use of anti-HER2–targeted therapy beyond disease progression. EGFR and c-met amplification, as well as PIK3CA mutation, are rarely associated with acquired resistance. Our results highlight the importance of formal

• br Multiple sclerosis MS is an immune mediated disease of

  2022-03-14

  

  Multiple sclerosis MS is an immune-mediated disease of the human CNS with a pathological signature featuring immunocyte infiltration, altered cytokine production, oligodendroglial degeneration, astrogliosis, microglial activation, multifocal demyelination and axonal degeneration (Schipper, 2004b)

• Compound containing dimethylglutarimide P cap P propyl

  2022-03-14

  

  Compound containing, dimethylglutarimide P-cap, P propyl group, α-methylbenzyl urea resulted in inhibitor with much improved binding (=0.064μM) and EC=0.3μM. This was an aza-peptide analog with an EC comparable to our first generation clinical candidate . Analog was evaluated for its selectivity aga

• br Acknowledgments br Introduction Guanosine cyclic

  2022-03-14

  

  Acknowledgments Introduction Guanosine 3′,5′-cyclic monophosphate (cGMP) is a signaling molecule with key roles in diverse (patho) physiological responses and processes in numerous prokaryotes and all eukaryotes. The number of reports stating the role of cGMP in different processes in plants i

• Whereas binding of activated RhoA

  2022-03-14

  

  Whereas binding of activated RhoA to the PH domains of the RhoGEFs is proposed to mediate positive feedback regulation (Chen et al., 2010b, Medina et al., 2013), the sequestration of p190RhoGEF by activated Rac1 reveals a novel putative physiological role, that is to utilize Rac1 to directly drive r

• Studies of human and mouse GPR as ascertained by

  2022-03-12

  

  Studies of human and mouse GPR84, as ascertained by mRNA levels in various tissues, have determined that GPR84 is highly expressed on bone marrow cells, splenic T and B cells, and circulating granulocytes/monocytes/macrophages. In the latter cells, mRNA expression of is up-regulated only under infl

• Finally a potentially effective therapeutic

  2022-03-12

  

  Finally, a potentially effective therapeutic approach is to target the LDH enzymes that mediate bidirectional conversion of pyruvate into lactate. In particular, because LDHA is the predominant isoform expressed in glycolytic tumours, an array of LDHA-targeting compounds have been proposed and valid

• For several years CXCL had

  2022-03-12

  

  For several years, CXCL17 had been classified as an orphan chemokine, until Maravillas-Montero et al. claimed that orphan G-coupled protein receptor GPR35 is the receptor of CXCL17 [15], [16]. However, no following research has been produced to further explore the function of the CXCL17-CXCR8 (GPR3

• Finally we investigated increasing basicity

  2022-03-12

  

  Finally, we investigated increasing basicity as a way to improve solubility. We expected that conversion of the ether linkage of to an -methyl group could improve solubility. More than expected, levosimendan demonstrated significant improvement of values of solubility for the two media, especiall

• We found that most antigenic regions in GlyT C

  2022-03-12

  

  We found that most antigenic regions in GlyT1C are located in the second half of the GlyT1C-terminus, which is in concert with previously published results (Olivares et al., 1994). We however further show that in contrast to epitopes 554–625 which are affected by calcium only minimally, the epitopes

• In our study we evaluated

  2022-03-12

  

  In our study we evaluated adenovirus type 5 (Ad5) as a vehicle for delivering Cre recombinase in conditional transgenic mouse based on the Cre-loxP system, in order to achieve GlyT1 gene modulation in a specific thalamic region in the adult animal. GlyT1 is a sodium- and chloride-coupled glycine tra

• br Regulation of Glu transporters The

  2022-03-12

  

  Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino GW9508 calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These include transcription

• br Methods GLUT DS was diagnosed

  2022-03-12

  

  Methods GLUT1DS was diagnosed either when analysis of the SLC2A1 gene showed a pathogenic mutation and/or when cerebrospinal fluid (CSF) analysis met the criteria for GLUT1DS: a CSF sglt-2 below the 10th percentile, a cerebrospinal fluid (CSF) to blood ratio below the 25th percentile and CSF lact

• br Acknowledgements The authors are grateful for

  2022-03-12

  

  Acknowledgements The authors are grateful for funding provided by the Health Research Council of New Zealand. Introduction Glucose is the most important energy carrier of the brain. Glucose transporter type 1 (Glut1) is located at the blood–brain barrier and assures the energy-independent, fa

• Animal studies have shown that various antidepressant

  2022-03-12

  

  Animal studies have shown that various antidepressant treatment are capable of upregulating GR protein and mRNA in key Pyoluteorin regions including the hippocampus and decreasing basal and/or stress-induced glucocorticoid secretion [37]. Changes in the level or function of GR regulate the negative

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