• Due to the presence of

  2022-02-15

  

  Due to the presence of all FGFRs in the epithelium, there are several FGFs ligands that could be binding to these FGF receptors, namely FGFs 1–4, 8–10, 16 and 18–20. By evaluating the known roles of FGFs in epithelial-mesenchymal interactions and in bone development, this list can be reduced. For ex

• br Introduction For decades regulated apoptosis and unregula

  2022-02-15

  

  Introduction For decades, regulated apoptosis and unregulated, accidental necrosis have been considered as the two sole cell death routes in multicellular organisms. With the beginning of the 21st century a paradigm shift has been witnessed by researchers in the field with the recognition that ma

• There are limited studies on antibody

  2022-02-15

  

  There are limited studies on antibody responses against HIV-1 integrase antigen. According to previous studies, almost 5 percent of individuals infected with HIV never raise anti-integrase SU11274 (Rikhtegaran Tehrani et al., 2015; Chang et al., 1985). If this rate is identical in individuals infec

• Although the presence of histamine secreting bacteria

  2022-02-15

  

  Although the presence of histamine-secreting bacteria has been well documented in foods, their presence within the human gut microbiota has not been investigated in detail. We recently performed an analysis of fecal samples from 161 volunteers to quantify the presence of bacterial HDC, using primers

• FoxM a downstream target of Gli has

  2022-02-15

  

  FoxM1, a downstream target of Gli, has been mainly related to Rosiglitazone synthesis regulation and cellular proliferation in tumor (Alvarez-Fernandez and Medema, 2013, Halasi and Gartel, 2013, Teh et al., 2002). Especially, FoxM1 is a regulator of G1/S and G2/M transitions and M-phase progression

• Anti apoptotic Bcl proteins have become

  2022-02-15

  

  Anti-apoptotic Bcl-2 proteins have become attractive targets for anti-cancer agents development, because they are associated with progression of a wide variety of human cancers., , The small-molecular Bcl-2 inhibitor venetoclax (ABT-199) () has been approved recently for the treatment of patients w

• At days and hours after MI the

  2022-02-15

  

  At 21 days and 24 hours after MI, the protein expressions of active JNK1 (P protein AZD-9291 of p38 was down-regulated only at 21 days after MI (P Discussion This study demonstrates the role of GSTP1 in HF by inhibiting the TRAF2-induced MAPK activation and the potent inhibitory effect of GSTP1

• The isoenzyme hGSTP is an attractive drug

  2022-02-15

  

  The isoenzyme hGSTP1-1 is an attractive drug target due to its high levels of disease association (target validation) and druggability (target tractability) properties [5,6,[17], [18], [19], [20], [21]]. hGSTP1-1 functions as a homodimer protein [18]. Each monomer has two domains, an α/β domain (N-t

• Compounds and were synthesized according to The synthesis

  2022-02-14

  

  Compounds –, , and were synthesized according to . The synthesis of compounds – commences with C-acylation of 3,4-dibromothiophene to the form ketone , the ring closure to form the ester , Hiyama cross-coupling or Suzki cross-coupling to produce , or to , respectively. Compound was produced from ket

• A high throughput screening campaign of

  2022-02-14

  

  A high-throughput screening campaign of the Lilly corporate compound collection led to the discovery of as potent and selective inhibitor of GlyT1 (IC=45nM, GlyT2 IC>30,000nM). In addition to the characteristic -methyl glycine moiety as acidic head group and the novel ethanolamine linker, also cont

• Previously localization studies have been conducted

  2022-02-14

  

  Previously, localization studies have been conducted using antibody-based detection of Pgp protein in tissues of Clade V nematodes. In transgenic C. elegans, Cel-Pgp-3 and Cel-Pgp-1 proteins localized to the apical membranes of the excretory and intestinal cells and the anterior pharynx (Broeks et a

• Studies of human and mouse GPR as ascertained by mRNA

  2022-02-14

  

  Studies of human and mouse GPR84, as ascertained by mRNA levels in various tissues, have determined that GPR84 is highly expressed on bone marrow cells, splenic T and B cells, and circulating granulocytes/monocytes/macrophages. In the latter cells, mRNA expression of is up-regulated only under infla

• The discovery that GLUT in the microvasculature

  2022-02-14

  

  The discovery that GLUT1 in the microvasculature represents an important target of VEGF thereby affecting Cladribine receptor function is highly relevant. The work of Jais et al. identified VEGF as a determining player in the regulation of cognitive performance and provides an important link to the

• iib iiia inhibitors Such responses have led to

  2022-02-14

  

  Such responses have led to the idea that elasmobranchs may be glucose intolerant. However, certain species, such as the North Pacific spiny dogfish (Squalus suckleyi; note that the species used in this study was previously referred to as Squalus acanthias but a study by Ebert et al. (2010) provided

• The post translational modification O GlcNAcylation

  2022-02-14

  

  The post-translational modification O-GlcNAcylation is also dependent upon glucose fluctuations. O-GlcNAcylation has been linked to insulin resistance and glucose toxicity in diabetes and its comorbidities [11]. O-GlcNAcylation is a dynamic modification tightly regulated by the nutritional sensor UD

14982 records 506/999 page Previous Next First page 上5页 506507508509510 下5页 Last page