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N fowleri enters the host through the
2021-03-24
N. fowleri enters the host through the nasal cavity and travels via the olfactory nerve into the Almorexant where it causes PAM (Visvesvara and Stehr-Green, 1990). The ameba most commonly infects healthy young adults and children and is able to evade the immune system but also elicits extensive dama
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Currently it is not known if drought
2021-03-24
Currently, it is not known if drought induces changes in the cysteine protease Tetrazole of soybean nodules. The available annotation of the soybean genome, in Phytozome (www.phytozome.net) has identified 706 C1 cysteine protease sequences and 75 C13 cysteine proteases. We have previously reported
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The protein levels of the three enzymes in
2021-03-24
The protein levels of the three enzymes in the organs in the three earthworm species ranked body wall > intestine > seminal receptacle ≈ seminal vesicle (Fig. 3B).The presence of significant detoxification capability in the body wall would be logically expected in a soil dwelling organism, to facili
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Cryoprotectant equilibration and the response to ice concent
2021-03-24
Cryoprotectant equilibration and the response to ice concentrated media are the two facets of cellular cryobiological protocols most commonly covered by mathematical modeling. In these models, Bcl Family Set I receptor are typically assumed to have uniform, spatially independent extracellular concen
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br Conflicts of interest br
2021-03-23
Conflicts of interest Acknowledgments This research was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (NRF-2015R1A2A2A01004593). Introduction Resistance to Inhibitors of Cholinest
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Similarly to other investigations the
2021-03-23
Similarly to other investigations, the present study found that ZEA in high concentrations decreases viability of both normal (Liu et al., 2018, Zheng et al., 2018a, Zheng et al., 2018b) and cancer see more (Khosrokhavar et al., 2009, Kowalska et al., 2017). The toxic effect of ZEA observed by Liu
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A possible explanation for these observations has been provi
2021-03-23
A possible explanation for these observations has been provided by a recent study showing that EWS-FLI-1 increases the Skp2-mediated 26S proteasome degradation, decreasing p27 protein stability and preventing cell senescence [42]. Mechanism of action of EWS-FLI-1 Molecular analysis has revealed
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The most common pathology associated with FGR is poor placen
2021-03-23
The most common pathology associated with FGR is poor placental perfusion as a result of abnormal placentation [4]. Placental developmental disorders and insufficient hormone synthesis may lead to FGR [5,6]. However, the exact mechanism responsible for abnormal placental development remains unclear.
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br Material and methods br Results and discussion br
2021-03-23
Material and methods Results and discussion Conclusions Prostanoid-E receptor selective antagonists that inhibit EP2 or EP4 receptor activities may be used as a pharmacological strategy to limit cyst formation and ADPKD progression. Our study follows on from our previous observations of the
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Although information regarding the influence of PGE on cardi
2021-03-23
Although information regarding the influence of PGE2 on cardiac fibroblast cell growth is sparse, the effect of PGE2 on other cell types has been studied extensively, particularly in cancer and cancer cell lines where COX-2 is over-expressed. Constitutive high levels of COX-2 expression have been no
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br Halogenases Enzymatic C H activation
2021-03-23
Halogenases Enzymatic C–H activation leading to halogenation is another emerging area in biocatalysis [55,56]. Incorporation of halogen atoms during medicinal chemistry eff ;orts is a well-established practice, presenting an effective means to control the molecule’s bioactivity and physicochemical
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A wealth of studies support the key role
2021-03-23
A wealth of studies support the key role of high NO in promoting higher blood flow and thus greater O2 delivery to working tissues in healthy Tibetans and thus partly compensate hypoxia induced low arterial O2 content [7,9,27]. We observed high eNOS mRNA, protein and enzyme activity in Ladakhi women
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According to the Nomenclature Committee of the International
2021-03-23
According to the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB, 1992), peptidases are divided into two classes, namely exopeptidases and endopeptidases, based on their actions on substrates and their active sites, respectively. Endopeptidases inclu
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Family and twin studies have estimated
2021-03-23
Family and twin studies have estimated the heritability of obesity to be between 40 and 70% [5], [6], [7]. However, all known risk variants can only account for ∼3% of the variance in BMI [8], [9]. Therefore, alternate methods are needed to identify additional risk factors. In recent decades, Drosop
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The different diagnostic outcomes of the
2021-03-22
The different diagnostic outcomes of the two assays are also dependent on the used stimuli. The QuantiFERON-CMV assay targets CD8 + T T0901317 by using peptides whereas the T-Track-CMV targets CD4+ and CD8 + T cells by stimulation with two viral proteins [18]. In our study, a specificity of 100% w
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