• br Introduction The ubiquitination status of a

  2021-01-09

  

  Introduction The ubiquitination status of a target protein is achieved via a delicate balance between two opposing forces: ubiquitin E3 ligases and DUBs. It has been postulated that the majority of proteins in a cell are regulated and modified by ubiquitin at some point (Hershko and Ciechanover,

• br Materials and methods br Results

  2021-01-09

  

  Materials and methods Results Discussion UPP components including the proteasome, E1s, E2s, E3s and DUBs may become one the most important 2 ag of therapeutic targets for the pharmaceutical industry in the near future and supersede those which are involved in the phosphorylation system [26

• br Conflict of Interest br Acknowledgements Marques

  2021-01-09

  

  Conflict of Interest Acknowledgements Marques F. was supported by the Foundation for Science and Technology (FCT), Portugal, Grant UMINHO/BI/35/2012. This work was supported by FCT by the Project PTDC/AGR-AAM/70418/2006. Introduction β-methylamino-l-alanine (BMAA) exposure has long been as

• The first transcription factor TF known to interact with one

  2021-01-08

  

  The first transcription factor (TF) known to interact with one of the cis-acting GAREs is GAMYB protein, the expression of which is induced by GA in the aleurone nrf2 inhibitor of barley (HvGAMYB) (Gubler and Jacobsen, 1992). GAMYB is an important regulator of endosperm functions during seed develo

• AZ3146 Recent data obtained with etifoxine suggest that faci

  2021-01-08

  

  Recent data obtained with etifoxine suggest that facilitation of GABAergic inhibition may be also associated with an indirect mechanism implying activation of the peripheral benzodiazepine receptor with a subsequent increase in neurosteroid production (Schlichter et al., 2000, Verleye et al., 2005).

• Moreover the vibrational contributions provide a

  2021-01-08

  

  Moreover, the vibrational contributions provide a plausible explanation for the missing X′ peaks in the experimental PES for the Er and Tm complexes. The current SO-MCQDPT2 (Fig. 1(k) and (l)) and MCQDPT2 II (Fig. 2(k) and (l)) calculations suggest the appearance of peak splittings for these complex

• The V V process of the FPGA development includes equivalence

  2021-01-08

  

  The V&V process of the FPGA development includes equivalence checking (Huang and Cheng, 1998, Huang et al., 2000, Kuehlmann and Krohm, 1997, Kuehlmann et al., 1995, Burch et al., 1994) as well as the simulation techniques. The equivalence checking can prove that two given designs have the same funct

• br Materials and methods br

  2021-01-08

  

  Materials and methods Results Discussion The nitric oxide generating enzymes of the NOS family comprise three isoforms: nNOS, iNOS and eNOS [31]. Expression of eNOS is mainly found in endothelial hydrochloride where it physically promotes vasodilation [32]. Conversely, evidence also indica

• The LNX ligand of numb protein

  2021-01-08

  

  The LNX (ligand of numb protein-X) or PDZRN (PDZ and RING) family of proteins consists of five members (LNX1–LNX5), the first four of which act as E3‐ubiquitin ligases in various roles, as reviewed elsewhere [14]. LNX proteins comprise a RING domain and two to four PDZ (PSD-95, DlgA, ZO-1) domains [

• Protein deubiquitination is becoming increasingly instrument

  2021-01-08

  

  Protein deubiquitination is becoming increasingly instrumental in understanding the complexities of the Ub system. Adding to this complexity is the discovery of bacterial effectors with DUB activity that have structurally adapted themselves to interfere with the eukaryotic Ub system (Pruneda et al.,

• br Introduction As a strong analgesic

  2021-01-08

  

  Introduction As a strong analgesic, morphine is often used to treat acute and chronic pain. However, morphine is a substance with low lipid solubility that slowly enters the nerve tissue through the blood–brain barrier and produces neurotoxicity. Morphine-induced neurotoxicity can be produced aft

• Kluveromyces lactisSimilar to S cerevisiae K lactis is a fac

  2021-01-08

  

  Kluveromyces lactisSimilar to S. cerevisiae, K. lactis is a facultative anaerobic respiratory yeast, which lacks Complex I in its mitochondrial respiratory chain. However, both yeasts differ regarding their respiratory-fermentative metabolism as K. lactis exhibits a greater use of the pentose phosph

• Our results on the acute effects of

  2021-01-07

  

  Our results on the acute effects of THC on resting state salidroside function are in line with previous neuroimaging findings. Increased perfusion after THC administration in insular and prefrontal regions has previously been reported in smaller samples (Mathew et al., 1997, Mathew et al., 2002, va

• br Introduction Phosphorus P is an

  2021-01-07

  

  Introduction Phosphorus (P) is an important nutrient for plant growth; however, in many regions of the world soils are low in plant-available P (Holford, 1997). Therefore, P fertilisers play an important role in agriculture. Most P fertilisers in current use are derived from phosphate rock; howev

• It is of interest that an initial

  2021-01-07

  

  It is of interest that an initial maternal experience in virgin mice produces both changes in subsequent maternal behavior as well as possible changes in neural gene expression. Stolzenberg et al. (2012) proposed that experience-based changes in maternal responsiveness may be mediated by chromatin m

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