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In the past few years neuroprotection
2020-11-09
In the past few years, neuroprotection via GLP-1R activation has been shown in several animal models of stroke, Alzheimer's, Parkinson's, Huntington's, ALS and traumatic BYL719 mg injury. This research field is rapidly growing and several reviews have been recently published (Darsalia et al., 2014b
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Enzymatic assay The usual in
2020-11-06
Enzymatic assay. The usual in vitro test for the measure of the activity of DbH involves ascorbate as a cosubstrate (e.g., 5mM) and tyramine as a substrate (e.g., 10mM). When using N-aryl-N′-hydroxyguanidines instead of ascorbate, the hydroxylase activity of DbH was measured by HPLC as the amounts o
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Saito et al reported that
2020-11-06
Saito et al. reported that diabetic bone has lower lysyl oxidase-derived enzymatic cross-links in collagen compared to non-diabetic bone, based on studies performed in a rat model [9]. Lysyl oxidase plays a pivotal role in bone development and function, as revealed in classical studies [10], [11]. L
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TMC120 Two nutrient sensing pathways the cAMP protein kinase
2020-11-06
Two nutrient-sensing pathways, the cAMP-protein kinase A (PKA) pathway and the target of rapamycin complex 1 (TORC1) pathway, are implicated in Msn2/4 regulation. Under non-stress conditions, Msn2 localizes in the cytoplasm and is inactivated by both PKA-dependent phosphorylation of the nuclear loca
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Our results are the first to
2020-11-06
Our results are the first to demonstrate that ERRγ acts as a catabolic regulator of cartilage degeneration and OA pathogenesis, and collectively support the idea that ERRγ could be a therapeutic target for OA Introduction DNA cytosine-5-methyltransferases (Dnmts) catalyze the methyl transfer fr
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ROS generation is crucial for NETs release upon
2020-11-06
ROS generation is crucial for NETs release upon both physiological or pathogenic stimuli [16,30]. In our study, we further verified this conclusion by demonstrating that SRA stimulation by Poly I enhanced intracellular ROS levels while scavenging of ROS by anti-oxidant agents effectively abolished t
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Future advances in the in vivo molecular imaging
2020-11-06
Future advances in the in vivo molecular imaging of enzyme activity will greatly benefit from the progress towards the quantitative detection of enzymes. Quantitative imaging requires knowledge of both the location and concentration of a specific enzyme, which is dependent on the simultaneous measur
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PI K Akt eNOS signaling is long been
2020-11-06
PI3K-Akt-eNOS signaling is long been known as a cell survival pathway in cardiology [8]. Current study has shown that ginsenosides, which is demonstrated to exhibit cardioprotective effect in several aspects, prevented cardiac ischemia/reperfusion injury via upregulation of PI3K and phosphorylations
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For most enolases fluoride acts as
2020-11-06
For most enolases, fluoride acts as an inhibitor, while Mg2+ is the most important metal activator. In yeast systems, metal cations and fluoride bind to enolase at the active center of the enzyme, forming a complex. The complex blocks the binding of substrates to the enzyme in yeast systems, thereby
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br In some but not all human vessels a
2020-11-06
In some, but not all, human vessels, a small population of ETB (usually Zanamivir with atherosclerotic lesions did not show any increase. In agreement, in experimental medicine studies in both heart failure patients and volunteer controls, selective ETA antagonism (BQ123) caused the expected pote
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br Introduction Increasing investigations show that the eart
2020-11-06
Introduction Increasing investigations show that the earthworm extract has various beneficial pharmacological activities, including fibrinolytic [2] and anticoagulative activity [3], anti-inflammatory activity [4], anti-oxidative activity [5], [6], peripheral nerve regeneration [7], bone regenera
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The idea that ASB can drive compartment
2020-11-06
The idea that ASB11 can drive compartment expansion in the CNS is further supported by in vitro work in human neuronal precursors. Nerve growth factor (NGF)-induced differentiation of PC12 pheochromocytoma Methicillin sodium salt [11] and RA-induced human pluripotent teratocarcinoma carcinoma (NT2)
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Studies on the external dehydrogenases of N crassa have show
2020-11-06
Studies on the external dehydrogenases of N. crassa have shown that the NDE1 protein is a Ca2+-dependent external NADPH dehydrogenase, while NDE2 is characterized as a dehydrogenase oxidizing both cytosolic substrates (external NADH and/or NADPH) (Carneiro et al., 2004, Melo et al., 2001). All three
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STI571 br Materials and methods br Results Recently a
2020-11-05
Materials and methods Results Recently, a quantitative proteomic analysis of C2C12 mouse myoblasts cell line totally deprived of protein kinase CK2 catalytic subunits (CK2α/CK2α′(−/−)), suggested that the cellular expression of HSP27, a chaperone with multiple functions related to proteostasis
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Chk is dramatically induce by
2020-11-05
Chk is dramatically induce by the IL-4 family of cytokines and equally dramatically inhibited by IFN-γ, a regulation that appears to be specific for human monocytes. In primary human T cells, Chk is not normally present, but it can be induced by potent activators of T Bay 11-7085 such as PHA or IL-
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