• In conclusion we have discovered two new

  2020-11-02

  

  In conclusion, we have discovered two new derivatives ( and ) that are potent inhibitors of DHODH. H and C NMR spectroscopic data revealed that these compounds undergo ready isomerisation at room temperature in -DMSO, but the docking studies indicate that there is neither conformation nor configurat

• Cerulenin For the SAR optimization of the right hand side

  2020-11-02

  

  For the SAR optimization of the right hand side, it was decided to explore the inclusion of the key carboxylic Cerulenin moiety present in the original DGAT-1 inhibitors from . Analogs were constructed by the synthetic routes outlined in , . In , the methylene-oxy linker was introduced by condensat

• br Introduction Biocatalysis can be used

  2020-11-02

  

  Introduction Biocatalysis can be used to synthesize chiral building blocks, such as monomers for polymer materials, and precursors for pharmaceuticals [[1], [2], [3], [4]]. Enzymes are very suitable for catalyzing reactions with high enantioselectivity to obtain chiral products. For instance, alc

• br Materials and methods br Results br

  2020-11-02

  

  Materials and methods Results Discussion Our previous investigation demonstrated that some genes in the latex that were involved in rubber biosynthesis were regulated by exogenous JA, and Hbvp1 is one of the JA-responsive genes in the latex of rubber trees [23]. In this study, the Hbvp1 enc

• Introduction Angiotensin II Ang II and Endothelin

  2020-11-02

  

  Introduction Angiotensin II (Ang II) and Endothelin 1 (ET-1) are potent vasoconstrictive peptides recognized as key players in many cardiovascular diseases [1]. Cardiac hypertrophy, ischemic arrhythmia, and stroke have been associated to an overstimulation of the angiotensin II type 1 (AT1) recepto

• In this work we fabricated a kind of multifunctional

  2020-11-02

  

  In this work, we fabricated a kind of multifunctional nanoparticles, based on HAuNS coated by chitosan-stearic Berberine hydrochloride copolymer (CSO-SA), which was employed frequently to form micelles for hydrophobic drug delivery in our previous work [21], [22]. The nanoparticles can encapsulate

• br Materials and methods br Results br Discussion

  2020-11-02

  

  Materials and methods Results Discussion PKA and Epac are two principal effector proteins involved in cAMP signaling; they are expressed in a wide range of tissues and control diverse biological functions [10]. The existence of two cAMP effectors provides more precise regulation of cAMP sig

• br Materials and methods br Results br Discussion Anti EGFR

  2020-10-31

  

  Materials and methods Results Discussion Anti-EGFR therapy for epithelial carcinomas has important clinical significance, but widespread intrinsic or acquired resistance seriously affects efficacy. Mutation and heterodimerization of EGFR are the two main causes of resistance to anti-EGFR th

• Initially the cause of hypoglycemia was not apparent There

  2020-10-31

  

  Initially, the cause of hypoglycemia was not apparent. There was no detectable lesion in the pancreas on plain computed tomography, and anti-insulin antibody was negative. Eight hours after hospital admission, his son discovered that the patient had accidentally taken glimepiride 3mg/day for 3 days.

• DIDS australia Proteases as multifunctional enzymes play key

  2020-10-31

  

  Proteases, as multifunctional enzymes, play key roles in controlling a wide variety of cellular and extracellular processes in plants and animals, including protein degradation and processing, germination, complement activation, inflammation, responses to environmental stimuli, senescence and so on.

• We hypothesized that the atopic phenotype

  2020-10-31

  

  We hypothesized that the atopic phenotype may be partially influenced by an altered binding and/or signalling due to the amino-acid substitution in the receptor protein. The principal aim of this study was to investigate the signalling mechanisms of the variants CysLT1-G300S and CysLT1-I206S induced

• br Future direction and conclusion br Conflict of

  2020-10-31

  

  Future direction and conclusion Conflict of interest References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Introduction Colony stimulating factor-1 (CSF-1; also referred to as the macrophage-colony stimulating

• Constitutive activity of Ras Raf MEK ERK pathway

  2020-10-31

  

  Constitutive activity of Ras/Raf/MEK/ERK pathway plays a critical role on melanoma growth, thus inhibition of activity of Ras, Raf and MEK can reduce ERK activity, leading to a decrease in melanoma cell proliferation, survival and invasion (Burotto et al., 2014; Paluncic et al., 2016). Our results a

• Metal ions are known not

  2020-10-31

  

  Metal ions are known not to be necessary for catalytic activity of serine proteinases. Nevertheless, Co2+ and Ca2+ ions were found to stabilize glutamyl endopeptidase molecule [1], [7], [19]. In our previous study, we have described significant stimulating effect of Ca2+, Mg2+, and Co2+ on biosynthe

• In our recent study we established

  2020-10-31

  

  In our recent study, we established a procedure to examine the chromatin binding of XRCC4 using a biochemical fractionation analysis using a detergent Nonidet P-40 [22]. In this study, we investigated the role of LIG4 and its subdomains in the recruitment of XRCC4/LIG4 complex to chromatin. Mater

14917 records 773/995 page Previous Next First page 上5页 771772773774775 下5页 Last page