• The DDR mediated lysyl oxidase induction in

  2020-06-24

  

  The DDR2-mediated lysyl oxidase induction in osteoblasts reported here is a novel function for this receptor. Various functions have been reported for DDR2. In an in-vitro study, Zhang and colleagues showed that DDR2 activation leads to Runx2 phosphorylation, which regulates osteoblast differentiati

• br Acknowledgements br Membrane bound proton translocating i

  2020-06-24

  

  Acknowledgements Membrane-bound proton-translocating inorganic pyrophosphatases (H-PPase; EC 3.6.1.1) belong to a recently identified category of proton pumps, distinct from F-, P-, and V-ATPases, which utilize pyrophosphate hydrolysis as the driving force for H movement across biological membr

• ML347 In addition to the blockade of airway smooth muscle

  2020-06-24

  

  In addition to the blockade of airway smooth muscle contractions, CysLT1 receptor antagonists also exerted a potent anti-inflammatory effect at this level. The oral administration of MEN91507, Pranlukast, Montelukast, and Zafirlukast also produced a long-lasting inhibition of leukotriene D4-induced

• Introduction Since the recognition of AIDS in more than thir

  2020-06-24

  

  Introduction Since the recognition of AIDS in 1981 more than thirty-five years ago, nearly 70 million individuals have been infected with human immunodeficiency virus type 1 (HIV) and roughly half have died (http://www.unaids.org/en/resources/documents/2016/AIDS-by-the-numbers). Although the introd

• Different types of environmentally induced antinociception h

  2020-06-24

  

  Different types of environmentally induced antinociception have been reported in a wide range of species (e.g., Behbehani, 1995, Bolles and Fanselow, 1980, Harris, 1996, Millan, 2002, Rodgers, 1995). According to Bolles and Fanselow (1980), fear and pain are independent and competing motivational sy

• Introduction Klebsiella pneumoniae a Gram negative enteric b

  2020-06-24

  

  Introduction Klebsiella pneumoniae, a Gram-negative enteric bacterium, is an organism with significance in both biomedicine and biotechnology. Some of the strains of K. pneumoniae are opportunistic pathogens, which can cause suppurative infection, pneumoniae and urinary tract infection in humans (B

• Here we explored the relative contribution of

  2020-06-23

  

  Here we explored the relative contribution of D1-like and D2-like receptor subtypes in the control of glutamate release, as well as their pharmacological properties and their interactions modulating the release. The pharmacological parameters (EC50 and Emax) of dopamine for the different types of re

• In this context we initiated a program to develop new

  2020-06-23

  

  In this context, we initiated a program to develop new antiviral chemotypes towards a host factor implicated in Hyperoside replication: the host (human) dihydrofolate reductase (DHFR) [21]. We recently identified this enzyme as the molecular target of 1-aryl-4,6-diamino-1,2-dihydrotriazines, struct

• br Materials and methods br

  2020-06-23

  

  Materials and methods Results Discussion The present work demonstrates the functional role of DGAT2 in elevating the neutral lipid accumulation in engineered N. oceanica, which have aroused a great deal of interest in industrial scale biofuel production. Recently, there have been increasing

• CK enzymes belong to a conserved family

  2020-06-23

  

  CK1 enzymes belong to a conserved family of serine/threonine protein kinases that plays an important and diverse role in vesicular trafficking, DNA repair, Irinotecan HCl Trihydrate progression and cytokinesis in organisms from yeast to humans [15]. In multicellular organisms CK1 enzymes also regul

• br Conflicts of interest br Introduction

  2020-06-23

  

  Conflicts of interest Introduction Arylamine N-acetyltransferase 1 (NAT1, EC 2.3.1.5) is a cytosolic enzyme that catalyses the acetylation of small molecule arylamines, hydrazines and sulphonamides (Hein, 2002). Found in most AG-126 in the body, NAT1 expression is regulated at the transcriptio

• br Introduction Cell transplantation therapies using embryon

  2020-06-23

  

  Introduction Cell transplantation therapies using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC)-derived retinal tissue (ESC/iPSC retina) or Pamidronate Disodium mg have emerged as therapeutic options for retinal degeneration following recent breakthroughs. A number of groups

• Finally it is possible that also species differences rat

  2020-06-23

  

  Finally, it is possible that also species differences (rat primary preadipocytes vs mouse 3T3-L1 cells) could contribute to these discrepancies. A recent study suggested that 3T3-L1 1,2-Dimyristoyl-sn-glycerol may contain adipocyte precursors with multiple cell lineage characteristics which may con

• Since ET was discovered first and showed

  2020-06-23

  

  Since ET-1 was discovered first and showed a wide variety of actions not only on the cardiovascular system but also on various other tissues, much information has accumulated on ET-1 compared with the two other peptides. The method for measurement of ET-1 levels in plasma or various tissues by means

• In all available E E structures the RING type

  2020-06-23

  

  In all available E2:E3 structures, the RING-type domain binds the E2 on a surface that is remote from the active site Cys (and therefore from the ubiquitin thioester) (Fig. 2). The non-contiguous E3-binding and active sites on the E2 imply that the role played by a RING to facilitate ubiquitin trans

15049 records 836/1004 page Previous Next First page 上5页 836837838839840 下5页 Last page